Abstract
The revolutionary concept of antigen detection by immunogold-silver staining (IGSS) has been evaluated for its applicability in the field of microbiology. We have successfully applied the method to identify various microorganisms (including Neisseria gonorrhoeae and Helicobacter pylori), to demonstrate phase- and antigen-variation of cell surface components, to discriminate adherence and entry of the bacteria into host cells, and to screen for isogenic variants (colony-immunoblotting). The method has proved to be a simple, valuable technique with a high sensitivity and with a broad spectrum of use. It is a powerful alternative to the conventional enzymatic and radioactive antigen detection methods. (The J Histotechnology 16:271, 1993)
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