Abstract
Aim:The aim of this study was to detect specific immunoglobulin (Ig) that could be used to determine monoclonal antibody in conjugate-making an effort for the indirect enzyme-linked immunosorbent assay (ELISA) diagnostic kit of toxocariasis in human.Materials and Methods:The study was conducted to assess the Ig profile, based on ELISA-isotyping, in mice infected with second stage larvae eggs of Toxocara cati. The optical density values of anti-T. cati mice serum IgG subclasses were analyzed by applying ANOVA factorial.Results:The specific IgG subclass in mice infected with T. cati mice was found to be IgG2β.Conclusion:Subclass of IgG, especially IgG2β, can provide leads about the use of the monoclonal antibody in conjugate making an effort for the indirect ELISA diagnostic kit.
Highlights
Subclass of IgG, especially IgG2β, can provide leads about the use of the monoclonal antibody in conjugate making an effort for the indirect enzyme-linked immunosorbent assay (ELISA) diagnostic kit
The disease caused by Toxocara cati infection in humans is a helminth zoonosis, which is mostly found in children [1,2]
About 31.9% of soil around slaughterhouses and about 20.6% of the soil around dairy farms were reported to contain eggs of Toxocara spp. included T. cati [6]. This situation could increase the risk of toxocariasis [7]. This finding supports the fact that human toxocariasis from infective eggs, containing second-stage (L2) larvae [8]
Summary
The disease caused by Toxocara cati infection in humans is a helminth zoonosis, which is mostly found in children [1,2]. About 31.9% of soil around slaughterhouses and about 20.6% of the soil around dairy farms were reported to contain eggs of Toxocara spp. included T. cati [6]. This situation could increase the risk of toxocariasis [7]. This finding supports the fact that human toxocariasis from infective eggs, containing second-stage (L2) larvae [8]. Human toxocariasis was the most prominent of all nematode diseases because it caused major health problems in children
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