Abstract
SummaryAntisera to mouse immunoglobulin heavy and light chains were used in vitro to inhibit the formation of rosettes in mouse spleen cell suspensions taken at intervals after sheep red blood cell immunization. Anti‐kappa produced greater than 90% inhibition of both immune and non‐immune rosettes. 65–80% inhibition of non‐immune and immune rosettes was induced by anti‐μ, up to 14 days after injection. Late in the response anti‐μ inhibited rosettes by less than 50%. Anti‐γ inhibited immune rosettes only, increasing to 42% inhibition on the 28th day of response. Anti‐α inhibited rosette formation only during the peak of the response. These results are discussed as relating to antigen‐binding receptors on rosette‐forming cells.
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