Abstract
By using affinity-purified antibodies to H1 0 and to H1AB the localization of these histones was studied by indirect immunofluorescence in the nuclei of proliferating (EAT and uninduced Friend cells) and of differentiating (induced Friend cells) cell populations. While with H1AB antibodies a bright fluorescence all over the chromatin was obtained, the localization of H1 0 varied depending on the state of the cell population. In the proliferating EAT cells it was localized strictly in the nucleoli. The Friend cell population revealed a heterogeneous picture with two types of H1 0 localization—nucleolar predominating in uninduced cell populations and peripheral predominating in induced cells. A comparison with literature data suggests that H1 0 seems to be associated with chromatin regions containing active genes.
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