Abstract
The present immunohistochemical study of human Peyer's patches and solitary lymphoid follicles have revealed that the PCV in these thymus-dependent areas has a specialized endothelium to which T and B lymphocytes generated in these follicles selectively adhere and then penetrate. The PCV endothelium shares antigens with a peripheral monocyte or macrophage subset which is HLA-DR+, OK-M5+ and OK-M1-. The presence of such antigens could be responsible for regulation of the lymphocyte passage through the venules, and for lymphocyte maturation, activation and proliferation during the migration. A possible route used by the lymphocytes traversing the PCV endothelium is discussed.
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