Abstract
The term immuno-inaotivation as distinct from neutralization is used to designate a technic by which the reaction between virus and antibody as well as by this reaction possibly induced changes in the virus are allowed to proceed to completion after which the residual virus activity is determined. The degree of inactivation was found to be inversely proportional to the amount of virus added. Maximum sensitivity wan thus obtained when the virus dose was reduced to the lowest possible limit. With due regard to this fact the technic was found to be 100 times more sensitive than the conventional neutralization test.
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