Abstract
The inactivating effect of ultraviolet light on viruses as well as bacteria has been observed repeatedly. That viruses so inactivated may be effective as immunizing antigens has already been shown for at least 2 viruses capable of causing disease in man. With a vaccine prepared by irradiating mouse-brain infected with rabic virus, Webster and associates1 successfully immunized mice and dogs against a subsequent injection of active virus. Salk, Lavin, and Francis2 compared the antigenic potency of epidemic-influenza virus following irradiation with that of active virus. In high concentrations, irradiated virus was nearly as effective an immunizing antigen as active virus; when lower concentrations were tested, a hundredfold loss in immunizing capacity was found to have occurred during irradiation. Ultraviolet light has been applied to the virus of equine encephalomyelitis, Eastern strain (E.E.E.), by Sharp and associates;3 they studied the molecular stability of ultraviolet-treated virus. The preparation o...
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