Abstract
Immunization of mice by intraperitoneal injections of an attenuated strain of Corynebacterium ovis led to the acquisition of a strong degree of resistance to infection with the virulent strain, measured as a greater bactericidal activity within the peritoneal cavity and a significant decrease in the development of internal lesions. The acquired immunity became manifest on about the fourth day after initial infection and was non-specific. It appeared to be associated with the resident mononuclear phagocytes of the immunized peritoneal cavity which were increased in numbers, larger in size and had altered staining properties.
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