Abstract
Spatzle is a key factor in Toll signaling pathway against microbe invasion. The spatzle4 gene from silkworm (Bmspz4) was successfully cloned in this study, it is the second cloned and studied gene in the Spz family besides Bmspz1 in the silkworm and it was cloned for the first time in silkworm integument. The spatzle4 gene expression was analyzed in different tissues of the third day fifth instar larvae and the highest expression was detected in the head, and secondly in integument. Microbe infection showed that BmSpz4 participated in immune response. The transcriptional expression of BmSpz4 was induced differentially between Gram-negative bacteria and Gram-positive bacteria or fungi. This study showed that Bmspz4 gene plays an important role in the innate immunity of integument of silkworm, Bombyx mori.
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