Abstract
Immune Reconstitution Inflammatory Syndrome in a Child with Disseminated Tuberculosis
Highlights
Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical reaction initially described in HIV-infected patient after the initiation of an antiretroviral therapy (ART)
TB associated IRIS is characterized by a clinical worsening after the start of ART in patients receiving Tb treatment
It can be diagnosed as a new presentation of TB that is «unmasked» in the weeks following the initiation of ART and the exclusion of other causes that could explain a deterioration [5]
Summary
We concluded from an extensive review of the literature that this case highlights a paradoxical immune mediated reaction to Mycobacterium tuberculosis during an appropriate anti-TB treatment. Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical reaction initially described in HIV-infected patient after the initiation of an antiretroviral therapy (ART). It can be diagnosed as a new presentation of TB that is «unmasked» in the weeks following the initiation of ART and the exclusion of other causes that could explain a deterioration (such as antimicrobial drug resistance, drug hypersensitivity reaction, or another opportunistic infection) [5].
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