Abstract
Multiple Myeloma (MM) is a hematological malignancy always preceded by a not malignant precursor state defined monoclonal gammopathy of undetermined significance (MGUS) and by a asymptomatic MM (smouldering MM, sMM). Immune dysfunction plays a key role in the pathogenesis of the disease, as demonstrated by the prognostic role of immunoparesis in the progression of MGUS and sMM into active MM (aMM). The aim of this study is to analyze the immune subsets distribution into plasma cells dyscrasias. A total amount of 895 bone marrow samples (170 MGUS, 188 sMM, 586 aMM) of 714 patients affected by plasma cells dyscrasias were studies at the different time point by flow cytometry for CD3, CD4, CD8, CD16, CD19, CD56, CD57, HLA-DR and Tgd antigens.
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