Abstract
Although there are many conditions to be met for the disease to occur (genetic predisposition, environmental factors, stress, exposure to pollutants, noxes, xenobiotics, diet), chronic inflammation is the way how the body responds to these substances. Excess weight leads to an alteration of the immune response, to an increased oxidative stress, and damage to the cellular Deoxyribonucleic acid (DNA) structure. The study aims to evaluate inflammation in obese mothers. The study group consisted of 30 pregnant women in which inflammation was analysed, with a mean age of 30.80 � 6,94 years old divided in 2 groups depending on their weight, that is 25 pregnant women with obesity and 5 normoponderal pregnant women. From the markers found in the blood samples, only CRP (AUC=0.740; IC95%: 0.466-1.014), leptin (AUC=0.616; IC95%: 0.296-0.936) and glycaemia (AUC=0.648; IC95%: 0.369-0.927) were good indicators of immune inflammation. The estimated risk of immune inflammation is 5 times higher in obese pregnancies with CRP levels above 6.
Highlights
There are many conditions to be met for the disease to occur, chronic inflammation is the way how the body responds to these substances
The development of obesity is associated with substantial modulation of adipose tissue structure, involving adipogenesis, angiogenesis and remodelling of the extracellular matrix
The group studied consisted of 30 pregnant women, obese (n=25), overweight and normal weighted (n=5), who were harvested blood samples to determine the level of markers associated with the inflammatory process: Creactive protein (CRP), leptin, insulin, glucose, Homeostatic Model Assessment for Insulin Resistance (HOMA)
Summary
DRAGOS VALENTIN CRAUCIUC1, ALLIA SINDILAR1*, MADALINA DIAC1*, DANIEL TABIAN1*, SOFIA MIHAELA DAVID1, DIANA BULGARU-ILIESCU1,2, EDUARD GRABRIEL CRAUCIUC1,3 1Grigore T.Popa University of Medicine and Pharmacy, Universitatii Str., 700115, Iasi, România 2Institute of Legal Medicine of Iasi, 4 Buna Vestire Str., 700455, Iasi, Romania 3Elena Doamna Clinical Hospital Iasi, 49 Elena Doamna Str., 700398, Iasi, Romania. Excessive fat accumulation in the abdomen is associated with increased cardio-metabolic risk, regardless of age. The mechanisms underlying this process are numerous and have as an essential cause that perivisceral adiposity is metabolically active. The development of obesity is associated with substantial modulation of adipose tissue structure, involving adipogenesis, angiogenesis and remodelling of the extracellular matrix. Obesity increases the risk of developing high blood pressure and excess protein in the urine after the 20th week of pregnancy. Women who are obese during pregnancy have an increased risk of developing thrombi (blood clots) in the deep veins of the lower limbs, a serious condition that may be complicated by pulmonary thromboembolism. Obesity in pregnancy increases the risk of the baby suffering from heart disease or diabetes as an adult. Changing the lifestyle can contribute to a healthier metabolic profile in obese pregnant women, which will reduce the risk of serious health problems in the product of conception
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