Immune Globulin for Infant Botulism

Abstract

Critical Care| April 01 2006 Immune Globulin for Infant Botulism AAP Grand Rounds (2006) 15 (4): 42–43. https://doi.org/10.1542/gr.15-4-42 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Immune Globulin for Infant Botulism. AAP Grand Rounds April 2006; 15 (4): 42–43. https://doi.org/10.1542/gr.15-4-42 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: immunoglobulins, infantile botulism Source: Arnon SS, Schechter R, Maslanka SE, et al. Human botulism immune globulin for the treatment of infant botulism. N Engl J Med. 2006;354:462–471. The authors from the California Department of Health Services report the results of both a randomized, double-blind, placebo-controlled trial of 122 infants with laboratory-confirmed cases of infant botulism, and an open label study of 382 patients with infant botulism treated with botulism immune globulin (BIG) within 18 days after hospital admission. For the randomized study, infants were eligible if they had acute flaccid paralysis consistent with infant botulism according to medical history, physical examination, and laboratory findings at admission. Enrollment was limited to the first 3 days of hospital admission. Stool specimens were sent for Clostridium botulinum toxin and culture; however, patients were generally treated before diagnosis confirmation by these studies. The treatment group received an intravenous infusion of 50... You do not currently have access to this content.