Abstract
Background Revealing novel cancer targeting biomarkers is a great challenge, and especially urging in cancer types with a more pronounced metastatic feature. We focus on potential anti-tumor immune reactions of the host. In order to harness the natural humoral immune response a novel immunological and molecular genetic panel assay has been developed for the investigation of patients with melanomas.
Highlights
Revealing novel cancer targeting biomarkers is a great challenge, and especially urging in cancer types with a more pronounced metastatic feature
We focus on potential anti-tumor immune reactions of the host
In order to harness the natural humoral immune response a novel immunological and molecular genetic panel assay has been developed for the investigation of patients with melanomas
Summary
Open Access “Immune B Cells know it better”: tumorimmunological panel assay to define tumor-associated antigen binding antibodies in patients with metastatic melanomas. Beatrix Kotlan1,2*, Timea Balatoni, Katalin Csirbesz, Judit Olasz, Orsolya Csuka, Laszlo Toth, Emil Farkas, Akos Savolt, Andras Szollar, Mihaly Ujhelyi, Szabolcs Horvath, Klara Eles, Miklos Kasler, Francesco M Marincola, Gabriella Liszkay
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