Abstract
The slow virus diseases are a fascinating example of an immunological enigma which may be at the center of the mechanism of slow virus disease pathogenesis. Studies on lymphocytic choriomeningitis (LCM) virus infection in mice showed that animals which had been inoculated at birth could suffer from a long continued infection with high titers of virus (Hotchin 1961, 1962). This “persistent tolerant infection” (PTI) (Hotchin and Weigand, 1961) was found to lead, after approximately 10 months, to a debilitating fatal disease (Hotchin, 1962; Hotchin and Collins, 1964). A brief look at this situation with LCM will introduce the main subject of my discussion.
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