Abstract
The immobilized Cu(I) on organic-inorganic hybrid material was prepared and used as effective catalyst for the Biginelli reaction. In the presence of immobilized copper catalyst, aromatic aldehydes reacted with β-keto ester and urea (or thiourea) smoothly to generate the corresponding Biginelli products in good to excellent yields without any additive. The work-up procedure is very simple and practical. Furthermore, the silica-supported Cu(I) could be recovered and recycled for eight consecutive trials without significant loss of its reactivity. Keywords: β-Keto ester, Biginelli reaction, Heterogeneous catalyst, Immobilization of Cu(I), Organic, inorganic hybrid material, Urea (thiourea), Dihydropyrimidin, alkaloids, aromatic aldehyde, hybrid catalysts
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