Abstract
Immobilization of a thyroid hormone substitute of L-thyroxine on chitosan-based smart hydrogel structure was performed to reduce the side effects of the required daily dose. The hydrogel was obtained by the Schiff reaction of chitosan with acetaldehyde and quaternization with methyl iodide then by ion exchange with NaCl salt. Finally, a hydrogel was obtained from the treatment of chitosan-based salt at -200C. The amount of levothyroxine immobilized by physical sorption on the hydrogel was determined by molecular electron spectroscopy on basis especially absorption peak at 227 nm. Results of IR- and UV-Vis spectroscopic analyses revealed that the interaction between levothyroxine and hydrogel occurs mainly due to hydrogen bonding and orientation forces of intermolecular interaction
Highlights
Hydrogels can be formed by the crosslinking reaction of linear or graft copolymers with small-molecules reagents by covalent chemical bonds
In order to increase the hydrophilicity of chitosan, its N,N-diethyl derivative was synthesized and quaternized with CH3I
By changing the iodine ions with chlorine, a DEMX salt of quaternary chitosan, which is better soluble in alkali medium, was obtained
Summary
Hydrogels can be formed by the crosslinking reaction of linear or graft copolymers with small-molecules reagents by covalent chemical bonds. The reference analysis shows that after loading levothyroxine on the chitosanbased hydrogels, the main focus is on its biological research and the study of the degree of release of the active drug into the medium. The nature of the bond between levothyroxine and the polymer chain has not been studied This directly affects the dose of immobilization drug molecules and the degree of activity of the drug, as well as the controlled release. In this regard, the Schiff's base of chitosan with acetaldehyde initially was synthesized, quaternized with methyl iodide, and NaCl ion exchange reaction, freeze modification, at the end levothyroxine immobilized into chitosan based gel, and the chemical nature of the interaction studied by spectroscopic methods. IR spectra of chitosan, levothyroxine and DEMX-levothyroxine hydrogel were recorded in the range of 4000–400 cm-1 and absorption bands characteristic of functional groups were observed
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