Immature Platelet Level in Stable Coronary Heart Disease (CHD) Patients with Diabetes Mellitus compared to Stable CHD Patients without Diabetes Mellitus

Abstract

Coronary heart disease (CHD) causes high mortality and morbidity in many countries. Immature platelet reactivity is one of the major causes of CHD thrombus formation due to its larger size and stronger aggregation properties than normal platelets. Though still controversial, diabetes mellitus (DM), which is one of the CHD risk factors, is mentioned to have a strong association with a high immature platelet level. Since studies on immature platelet in stable CHD are limited, the authors intended to search for the difference between immature platelet level in DM and non-DM patients with stable CHD. This research was an observational analytic study with a cross-sectional design; 31 samples of CHD patients who underwent coronary catheterization were obtained. The characteristics of the data was collected by completing a pre-operation form and the immature platelets were counted using an automated cytometry tool, SYSMEX XE 2100. They were analyzed using Pearson’s statistical analysis. There was no significant correlation between the immature platelet levels of DM and non-DM patients with stable CHD (p>0.05). There was a significant positive correlation between HbA1C and the immature platelet level (Immature Platelet Fraction, p <0.05; Immature Platelet Count, p <0.01) in stable CHD patients.