Abstract
The effect of ammonium chloride and sodium bicarbonate administration on urinary excretion of 14C‐imipramine in man and on tissue distribution of 14C‐imipramine in rats has been studied. Oral administration of ammonium chloride to man increased the total excretion of orally administered 14C‐imipramine about 10 to 40 per cent. This increase was due to a 50 to 100 per cent increase in excretion of nonconjugated metabolites. In particular the excretion of unchanged imipramine and desmethylimipramine was sensitive to changes in urinary pH. Compared to sodium chloride‐treated rats, in rats treated with ammonium chloride the uptake of 14C‐imipramine in brain was reduced some 15 per cent.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
