Abstract
This paper describes a new application of NMR imaging in material science. It shows that MRI is able to provide information in liquid chromatography inaccessible by existing investigation methods. Density gradients, wetting status, inner voids, cracks, and channels in chromatographic columns can be visualized and quantified noninvasively for the first time. Due to the lack of a method permitting real-time analysis of band profiles, most information about chromatographic performance and dynamics has been hitherto derived from postseparation analysis. We demonstrate that fast imaging techniques can allow the visualization of band shapes on the fly, even at the high velocities encountered under high-pressure conditions. Sodium imaging provides information on special kinds of chromatography. We believe that the method has high potential for further development.
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