Abstract
Background: To evaluate the role of a transrectal ultrasound (TRUS) guided biopsy and a color doppler test in the detection of prostate cancer in patients with increased serum prostate-specic antigen (PSA) levels and/or an abnormal digital rectal examination (DRE). A total of 30 cases, ranging in age from 50 to 80 yearsMethods: and showing increased serum PSA levels (>4ng/ml) and/or abnormal DRE, were enrolled and underwent TRUS evaluation followed by color Doppler owmetric studies. A TRUS-guided FNAC/biopsy was performed in all the cases. The ndings were conrmed histopathologically. Data were analyzed using the chi-square test. Histopathologically, a total of 11 casesResults: (36.66%) were malignant. On TRUS, irregular shape, heterogeneous echotexture loss of differentiation between the peripheral and internal zones, and capsular invasion were signicantly associated with malignancy. On owmetry, moderate vascularity and focal asymmetry were signicantly associated with malignancy. The combined use of TRUS and color Doppler owmetry was found to be 100% sensitive and 89.5% specic and had a positive predictive value (PPV) and a negative predictive value (NPV) of 84.6% and 100%, respectively. Trus with color doppler ultrasound plays an important role in the detectionConclusions: of prostatic malignancy with high sensitivity as well as specicity. The high negative predictive value, as observed in the present study could avoid unnecessary diagnostic invasive intervention.
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