Abstract
Tumors developing within a host induce a state of immune tolerance to tumor antigens. Number of concepts are tested in order to activate the antitumoral immune response to recognize and destroy tumor cells. Tumor vaccines genetically modified with cytokine genes (GMTV) are one of strategies currently examined. Different cytokines display different patterns of antitumoral immune response activation but the perfect cytokine or a combination of cytokine are still to be found. Here we present two GMTVs one consisting of cells producing IL-6 and the second producing GM-CSF in a murine tumor rejection model of Renal Cell Carcinoma (RenCa).
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