Abstract
Multiple myeloma (MM) is a genetically complex and heterogeneous disease with multiple genomic events associated with tumor development and progression.Chromosomal translocations into the immunoglobulin heavy-chain (IgH) locus on 14q32 are the main primary events, occurring in about 50% of total MM cases.Currently, there are five main chromosomal translocation partners involving with immunoglobulin heavy-chain (IgH), including t(4;14), t(6;14), t(11;14), t(14;16) and t(14;20). However, IgH translocation with undefined partner genes can still be found in 15% of all newly-diagnosed MM (NDMM) patient, and little is known about their survival.
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