Abstract
Background and Significance: Epigenetic effects on embryos produced from in vitro fertilization are unknown. Recent epidemiological studies show that individuals conceived through in vitro fertilization (IVF) are at twice the risk of birth defects which are associated with a loss of imprinting or altered imprinting of Igf2,and other genes, as compared with babies conceived naturally. These birth defects include diseases associated with aberrant imprinting, such as, Beckwith-Wiedemann Syndrome, Prader-Willi and Angelman’s Syndrome.
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