Abstract
In developed countries, every child will present to a primary health-care practitioner more than once every year with symptoms of an acute infection.1 Primary care physicians faced with such a child know that the likelihood of serious disease is about 1%, but what has not been clear is the evidence-based approach that clinicians should take in investigating such children. In The Lancet today, Ann Van den Bruel and colleagues2 address this uncertainty in a systematic review of 30 studies.
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