Abstract
BackgroundThe presence of diabetes mellitus (DM) is associated with increased liver morbidity and mortality risk in patients with chronic hepatitis B (CHB). Aim of this study was to identify factors associated with type 2 diabetes mellitus (T2DM) in CHB patients.MethodsA cross-sectional study with pair-matched controls was conducted in Nantong Third People’s Hospital, Nantong University, China. From January 2008 to December 2012, a total of 1783 CHB patients were screened for study subjects, among whom 207 patients with T2DM were enrolled as cases and 207 sex- and age-matched non-DM patients as controls. Demographic, anthropometric, lifestyle, clinical, and laboratory data were obtained from each subject.ResultsIn the univariate model, thirteen variables showed marked differences between the DM group and non-DM group. Patients with longer duration of CHB (≥15 years) and alcoholic steatosis showed the highest likelihood of T2DM (odds ratio = 5.39 and 4.95; 95% confidence intervals 2.76-10.53 and 1.65-14.91). In the multivariate adjusted analysis, three CHB-related factors, namely high viral load, long duration of illness, and presence of cirrhosis, contributed to substantially increase the likelihood of T2DM, in addition to the other five risk factors including family history of DM, low education level, elevated triglycerides (TG), gamma-glutamyl transferase (GGT) levels, and presence of alcoholic steatosis.ConclusionsOur findings suggest that high viral load, long duration of CHB, presence of cirrhosis, alcoholic steatosis and several other factors may be potential risk factors for development of T2DM in CHB patients. It is of vital importance to monitor glucose in high-risk CHB patients and aggressively intervene on modifiable risk factors.
Highlights
The presence of diabetes mellitus (DM) is associated with increased liver morbidity and mortality risk in patients with chronic hepatitis B (CHB)
Study population The CHB patients with type 2 diabetes mellitus (T2DM) (DM group) that formed the basis of this study comprised all patients who fulfilled the following criteria: (1) admitted to Nantong Third People’s Hospital, Nantong University (Jiangsu Province, China) between 1 January 2008 and 31 December 2012; (2) diagnosed as chronic hepatitis B or hepatitis B cirrhosis, without evidence of viral hepatitis other than hepatitis B; (3) complicated with newly diagnosed or previously known T2DM; (4) duration of diabetes not longer than that of hepatitis B surface antigen (HBsAg) positivity
After excluding patients who were co-infected with other hepatitis viruses, 1732 patients were recruited for the study
Summary
The presence of diabetes mellitus (DM) is associated with increased liver morbidity and mortality risk in patients with chronic hepatitis B (CHB). Aim of this study was to identify factors associated with type 2 diabetes mellitus (T2DM) in CHB patients. 300,000 patients die from HBV-related liver diseases each year in China [2]. While epidemiological studies have evaluated factors associated with the presence of T2DM in general population, the risk factors among CHB patients has not been explored. The aim of this hospital-based cross-sectional study was to identify risk factors associated with type 2 diabetes in patients with chronic hepatitis B
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
