Abstract
NADPH oxidase 5 (NOX5) is a transmembrane signaling enzyme that produces superoxide in response to calcium binding. NOX5 has been identified as a key player for a variety of physiological and pathological conditions, yet a comprehensive understanding of its role in the cell has been lacking. Here we present a workflow to identify NOX5 protein partners as well as proteins which become oxidatively modified in a NOX5 dependent manner. These protein candidates can then be assessed for their role in mediating NOX5 dependent signaling in the cell which is involved in cellular differentiation, angiogenesis, and human disease. Investigating these results will allow us to understand how NOX5 carries out its physiological roles as well as provide indications for how dysregulation can lead to the initiation and progression of disease.
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