Abstract
Three type III secretion system (T3SS) inhibitors (compounds 5, 19, and 32) were identified by virtual screening and biological evaluation. These three compounds were evaluated against a panel of Salmonella species strains including S. enteritidis, S. typhi, S. typhimurium, S. paratyphi, and S. abortus equi, and their minimum inhibitory concentrations ranged from 1 to 53 μg/ml. Especially, these compounds showed comparable activity as the of the positive control gatifloxacin towards S. abortus equi. The present results suggest that these new T3SS inhibitors could be used as a potential lead molecule for drug development of anti-Salmonella.
Highlights
Salmonellosis is a general term for infectious diseases of livestock and poultry caused by Salmonella bacteria
The present study provided new chemotypes for the development of novel T3SS inhibitors targeting SipD protein, which could serve as lead compounds for developing novel medications against Salmonella bacteria
Three novel T3SS inhibitors 5, 19, and 32 with different structural scaffold were first discovered based on virtual screening, and the in vitro anti-bacterial activities of these inhibitors against five stains of Salmonella sp. were evaluated
Summary
Salmonellosis is a general term for infectious diseases of livestock and poultry caused by Salmonella bacteria. Salmonella are mainly categorized into two species including Salmonella bongori and Salmonella enterica, especially the last of which has a large number of subspecies and serovars, and some of them, such as serovar Enteritidis, are highly pathogenic (Vullo et al, 2011). It mainly causes abortion or death of pregnant female animals, such as pigs, chickens, cattle, donkey and other animals, with the symptoms of fever, diarrhea, sepsis, gastroenteritis and meningitis, as well as intestinal damage in both humans and animals (Zha et al, 2019). There is an urgent need for the discovery of new anti-Salmonella drugs
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