Abstract
BackgroundDifferent factors have been introduced which influence the pathogenesis of chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC). COPD as an independent factor is involved in the development of lung cancer. Moreover, there are certain resemblances between NSCLC and COPD, such as growth factors, activation of intracellular pathways, as well as epigenetic factors. One of the best approaches to understand the possible shared pathogenesis routes between COPD and NSCLC is to study the biological pathways that are activated. MicroRNAs (miRNAs) are critical biomolecules that implicate the regulation of several biological and cellular processes. As such, the main goal of this study was to use a systems biology approach to discover common dysregulated miRNAs between COPD and NSCLC, one that targets most genes within common enriched pathways.ResultsTo reconstruct the miRNA-pathways for each disease, we used the microarray miRNA expression data. Then, we employed “miRNA set enrichment analysis” (MiRSEA) to identify the most significant joint miRNAs between COPD and NSCLC based on the enrichment scores. Overall, our study revealed the involvement of the targets of miRNAs (such as has-miR-15b, hsa-miR-106a, has-miR-17, has-miR-103, and has-miR-107) in the most important common biological pathways.ConclusionsAccording to the promising results of the pathway analysis, the identified miRNAs can be utilized as the new potential signatures for therapy through understanding the molecular mechanisms of both diseases.
Highlights
Different factors have been introduced which influence the pathogenesis of chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC)
The aim of this study is to identify the most significant miRNAs as the new biomarkers which are common between COPD and NSCLC via analyzing the shared pathways between both diseases
This study presents common miRNA biomarkers between COPD and NSCLC of pre-processed datasets via miRNA-pathway set enrichment analysis and highlights those pathways with more target genes of miRNAs associated with COPD and NSCLC
Summary
Different factors have been introduced which influence the pathogenesis of chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC). COPD as an independent factor is involved in the development of lung cancer. One of the best approaches to understand the possible shared pathogenesis routes between COPD and NSCLC is to study the biological pathways that are activated. COPD is recognized as an autonomous risk factor for lung cancer, for NSCLC as the most prevalent lung cancer type [9]. Both COPD and NSCLC are mostly caused by cigarette smoking [8] through inducing inflammation and oxidative stress in the lung [10]. Some common processes would contribute to the development of COPD and lung cancer in patients, such as abnormal immunity, cell proliferation, apoptosis, and chromatin modifications [11]
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