Abstract
BackgroundTo rummage autophagy-related prognostic, diagnostic, and therapeutic biomarkers in cervical cancer (CC).MethodsThe RNA-sequence and clinical information were from the TCGA and GTEx databases. We operated Cox regression to determine signatures related to overall survival (OS) and recurrence-free survival (RFS) respectively. The diagnostic and therapeutic effectiveness of prognostic biomarkers were further explored.ResultsWe identified nine (VAMP7, MTMR14, ATG4D, KLHL24, TP73, NAMPT, CD46, HGS, ATG4C) and three risk signatures (SERPINA1, HSPB8, SUPT20H) with prognostic values for OS and RFS respectively. Six risk signatures (ATG4C, ATG4D, CD46, TP73, SERPINA1, HSPB8) were selected for qPCR. We screened five prognostic signatures(ATG4C, CD46, HSPB8, MTMR14, NAMPT) with diagnostic function through the GEO database. Correlation between our models and treatment targets certificated the prognostic score provided a reference for precision medicine.ConclusionsWe constructed OS and RFS prognostic models in CC. Autophagy-related risk signatures might serve as diagnostic and therapeutic biomarkers.
Highlights
To rummage autophagy-related prognostic, diagnostic, and therapeutic biomarkers in cervical cancer (CC)
Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed 53 differently expressed autophagy‐related genes (DEARGs) were included in critical pathways associated with cancer development, such as apoptosis, autophagy—animal, platinum drug resistance and p53 signaling pathway
Among the 35 genes related to the overall survival (OS), 13 genes were protective with HR < 1, and 22 genes were dangerous with HR > 1 (Fig. 3a)
Summary
To rummage autophagy-related prognostic, diagnostic, and therapeutic biomarkers in cervical cancer (CC). The continuous infection of high risk human papillomavirus (HR-HPV). Autophagy has been discovered to play a momentous role in CC [6, 7]. Autophagy is an evolutionarily conserved important process in eukaryotes, which is responsible for the turnover of intracellular substances [8,9,10]. It has not been fully clarified whether autophagy plays a positive or negative role in physiological or pathological processes including cancer. Li et al discovered that high-risk HPV infection could promote the development of CC by inhibiting autophagy of the host [12]. Zhang et al reported that microtubule-associated protein 7 (MAP7) promoted the migration, invasion and progression of CC by regulating the autophagy pathway [13]
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