Identification of a novel HLA‐B allele HLA‐B*4059 in Chinese bone marrow donors†

Abstract

Tissue AntigensVolume 67, Issue 4 p. 339-340 Identification of a novel HLA-B allele HLA-B*4059 in Chinese bone marrow donors† X. Shan, Corresponding Author X. Shan Beijing Red Cross Blood Center, Beijing 100088, China *Prof Xiaoyan Shan Beijing Red Cross Blood Center No. 37 BeiSanhuan Middle Street Beijing 100088 China Tel: +86 10 62019338 Fax: +86 10 62019338 e-mail: bjdonorbank@yahoo.com.cnSearch for more papers by this authorG. Gao, G. Gao Beijing Red Cross Blood Center, Beijing 100088, ChinaSearch for more papers by this authorX. He, X. He Beijing Red Cross Blood Center, Beijing 100088, ChinaSearch for more papers by this authorG. Wu, G. Wu National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, ChinaSearch for more papers by this authorZ. Zhang, Z. Zhang Beijing Red Cross Blood Center, Beijing 100088, ChinaSearch for more papers by this author X. Shan, Corresponding Author X. Shan Beijing Red Cross Blood Center, Beijing 100088, China *Prof Xiaoyan Shan Beijing Red Cross Blood Center No. 37 BeiSanhuan Middle Street Beijing 100088 China Tel: +86 10 62019338 Fax: +86 10 62019338 e-mail: bjdonorbank@yahoo.com.cnSearch for more papers by this authorG. Gao, G. Gao Beijing Red Cross Blood Center, Beijing 100088, ChinaSearch for more papers by this authorX. He, X. He Beijing Red Cross Blood Center, Beijing 100088, ChinaSearch for more papers by this authorG. Wu, G. Wu National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, ChinaSearch for more papers by this authorZ. Zhang, Z. Zhang Beijing Red Cross Blood Center, Beijing 100088, ChinaSearch for more papers by this author First published: 24 April 2006 https://doi.org/10.1111/j.1399-0039.2006.00568.xCitations: 5 † A novel human leukocyte antigen (HLA) class I allele, B*4059, has been identified in routine typing of bone marrow donors for the Chinese Marrow Donor Registry in Beijing, China. The B*4059 allele differs from the closest matching allele B*4030 by six nucleotide substitutions in exon 3: nt 361 (G→A), 362 (T→A), resulting in an amino acid change from V(GTG) to R(AGG) at codon 121; nt 380 (G→C), resulting in an amino acid change fromV(GTG) to L(CTG) at codon 127; nt 388 (G→C), resulting in no amino acid change; nt 413 (A→G), resulting in an amino acid change from K(AAC)→D(GAC); nt 420 (A→C), resulting in an amino acid change from Y(TAC)→S(TCC). Four amino acid changes implicates a different specificity and affinity of antigen binding. † The name B*4059 has been officially assigned by the WHO Nomenclature Committee in June 2005. This follows the agreed policy that, subject to the conditions stated in the most recent Nomenclature Report ( 1), names will be assigned to new sequences as they are identified. Lists of such new names will be published in the following WHO Nomenclature Report. The nucleotide sequence reported in this paper has been submitted to the GenBank and was assigned the accession number AY961619. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume67, Issue4April 2006Pages 339-340 RelatedInformation