Abstract
The gut microbiota of insects is composed of a wide range of microorganisms which produce bioactive compounds that protect their host from pathogenic attack. In the present study, we isolate and identify the fungus Chrysosporium multifidum from the gut of Hermetia illucens larvae. Extract from C. multifidum culture broth supernatant showed moderate activity against a strain of methicillin-resistant Staphylococcus aureus (MRSA). Bioguided isolation of the extract resulted in the characterization of six α-pyrone derivatives (1–6) and one diketopiperazine (7). Of these compounds, 5,6-dihydro-4-methoxy-6-(1-oxopentyl)-2H-pyran-2-one (4) showed the greatest activity (IC50 = 11.4 ± 0.7 μg/mL and MIC = 62.5 μg/mL) against MRSA.
Highlights
IntroductionThe black soldier fly (BSF), is an insect native to the Americas whose larvae quickly colonize decomposing matter
Hermetia illucens, or the black soldier fly (BSF), is an insect native to the Americas whose larvae quickly colonize decomposing matter
An NCBI Blast search of the resulting sequence resulted in 100% identity and coverage with GenBank accession numbers AB861747.1 and AB359438.1, which correspond to Arthroderma multifidum, a telomorphic ascomycete [14,15]
Summary
The black soldier fly (BSF), is an insect native to the Americas whose larvae quickly colonize decomposing matter. Unaffected by their pathogen-rich diet, BSF efficiently produces a range of substances relevant to the animal feed and biodiesel industries [1,2]. Trichosporon asahii was shown to be active on strains of Candida glabrata and Candida lusitaniae [6] Other antibacterial substances such as peptides [7,8] and lipids [9] have been isolated from BSF, but information is still limited. The purpose of this work is to isolate and identify
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