Ideal timing of labor in terms of oxidative stress – which term period is best?

Abstract

Abstract Objectives To determine the ideal timing of labor for term pregnancies using oxidative stress determiners. Methods A total of 150 low-risk pregnant women were divided into three groups according to gestational week periods: early term, full term, and late-term. Groups were matched in terms of age and body mass index. Thiol/disulfide homeostasis parameters were obtained from maternal blood samples at the beginning of the active phase and from cord blood immediately after delivery. Results Maternal and fetal native and total thiol, which indicates antioxidant status, were found to be significantly higher in full terms (maternal 397.5 ± 78.8, 435.9 ± 84.5, and fetal 472.5 ± 78.4, 513.7 ± 89.2 respectively; for all parameters p<0.05). The maternal oxidant balance was not significantly different between the groups; 1st-minute APGAR scores were significantly correlated with maternal antioxidant levels (p=0.042; r=0.199). Conclusions The highest level of antioxidants in thiol/disulfide homeostasis in full-term pregnancies can be explained by the mechanism that increases the antioxidant level of the mother, which works best in the period between 39 and 41 weeks of pregnancy.