Abstract
Perivascular spaces (PVS), fluid-filled structures surrounding small blood vessels can become dilated in neurodegenerative conditions including Parkinson’s disease (PD). Enlarged PVS, which may reflect degeneration of dopaminergic neurons, has been shown to bias diffusion tensor imaging findings1. Recently, tractography has been used in imaging-based targeting for deep brain stimulation (DBS)2,3. DBS is an effective procedure in improving motor symptoms for patients with PD. Sensory and motor regions of globus pallidus interna (GPi) and subthalamic nucleus (STN) are commonly target sites for DBS. This study aimed to quantify the effect of enlarged PVS on corticopallidal and corticosubthalamic pathways using deterministic and probabilistic tractography in patients with advanced PD selected to undergo DBS.
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