Abstract
The evoked compound action potential (ECAP) is a measure of neural activation in response to spinal cord stimulation (SCS). Recent studies have used ECAPs to optimize paresthesia-centric tonic SCS1. However, contemporary SCS paradigms such as Differential Target MultiplexTM programming (DTMP) incorporate multiple stimulation signals including both low-rate programs (LRP) and high-rate programs (HRP). SCS based on DTMP has been studied both preclinically in rats and in clinical applications2,3, though little is understood about the effect that the multiplexed HRP have on the ECAPs elicited by LRP. Here4, we assessed whether a 1200 Hz HRP may have a dose-dependent effect on the ECAP elicited with 50 Hz LRP within a DTMP paradigm.
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