Abstract
Mammalian cells can maintain a relatively homogeneous cell volume distribution, while tumorigenic cells tend to have large cell size variability. At the short timescale, cell volume is determined by water flow across the membrane, which is driven by osmotic and hydrostatic pressure gradients across the cell surface. During processes such as mitotic swelling, spreading on the substrate, and response to change in media osmolarity, cells are able to dramatically change their volume within minutes or a few hours.
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