Abstract
Momordica charantia L. Var. abbreviata Ser. protein hydrolysates (MCPH) were prepared by enzymatic hydrolysis using Alcalase 2.4L. The acute hypoglycemic effect of MCPH at different degree of hydrolysis (DH) was investigated in alloxan-induced diabetic mice. The result showed the MCPH at 11% DH had the highest hypoglycemic effect. In the long-term study, repeated oral administration of MCPH at 11% DH for 28 days significantly reduced the fasting blood glucose (FBG) level, serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-c) levels in diabetic mice. At the same time, MCPH markedly increased body weight, serum high density lipoprotein cholesterol (HDL-c) after 28 days of treatment.
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