Abstract
Hypoglycemic effects of Korean red ginseng according to processing methods was investigated in STZ‐induced diabetic rats. Five weeks‐old SD rats were divided into 5 groups; normal control (NC) group, STZ‐induced diabetic (DM) group, red ginseng (RG) group, fermented red ginseng (FG)group and pupped red ginseng (PG) group. RG, PG and FG groups fed the corresponding ginseng powder (500mg/kg) for 7 weeks after single injection of STZ (50mg/kg, i.v.). Body weight gain looked to be more in three ginseng groups compared to DM group. At week 7, the FBS levels of the RG, FG and PG groups were reduced by 12.88%, 11.7% and 21.55% when compared with DM group. The AUC levels in OGTT was not significantly different among the groups Serum insulin and TG levels were most significantly improved in PG group and serum amylase level was increased in RG group(p<0.05). DNA damage of blood lymphocyte deceased in PG group. Histopathological results of pancreas showed that destruction of exocrine as well as endocrine might be prevented by red ginseng administration. Immunohistochemistry of glut2 were improved in the three ginseng treated groups. From this result, it was suggested that pupped ginseng could be a depressant of STZ‐induced toxicity.
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