Abstract
Objective: The study was aimed at investigating the hypoglycemic, antioxidant and Hepatoprotective effects of Chrysophyllum albidum in diabetes induced male Wistar rats. Methods: Ethanol root bark extract was administered to thirty rats of six groups A, B, C, D, E and F of five rats each, weighing between 150-170g. Diabetes was induced in Groups B, C, D, E and F using a single intraperitoneal injection of 140mg/kg of Alloxan after an overnight fast. Group A served as the normal control while Group B served as the diabetic control. Group C had metformin of 500mg while Groups D, E and F received 50, 100 and 200mg/kg / bw/ day of the plant extract respectively through orogastric intubation. All the animals were given normal rat chow and water freely. Blood glucose level was determined and the experiment lasted for 3 weeks. On day 21 after an overnight fast, animal were anaesthetized and blood samples were collected by cardiac puncture under inhaled chloroform for the determination of superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) assays. The liver function test, ALT, AST and ALP was determined. Result: This showed that C. albidum and metformin significantly (p < 0.05) lowered the Fasting blood glucose (FBS), the activities of SOD and CAT was dose- dependently increase when compared to the diabetic control and there was also a reduction of MDA in the treated groups. There was decrease in the activity of ALT, AST and ALP, which was also dose-dependent. Conclusion: The results showed that the plant has significant antidiabetic activity and could therefore be employed for the treatment of diabetes mellitus in which free radicals are implicated.Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 298-304 DOI: http://dx.doi.org/10.3329/bjms.v12i3.12721
Highlights
Diabetes mellitus is a chronic disorder of carbohydrate, fat and protein metabolism caused by either lack of insulin secretion or decreased sensitivity of the tissues to insulin[1]
Body weight There was a decrease in the body weight of diabetic control and treated groups when compared to the control animals that gained weight
Treatment of diabetic rats with ethanolic root bark extract of C. albidum (50, 100, 200mg/ kg body weight/ day) and metformin (500 mg kg-1) for 21 days after establishment of hyperglycemia resulted in significant reduction (P
Summary
Diabetes mellitus is a chronic disorder of carbohydrate, fat and protein metabolism caused by either lack of insulin secretion or decreased sensitivity of the tissues to insulin[1]. 3. Adeola Airat Bakare, Department of Anatomy College of Medicine of the University of Lagos. 4. Ini Ibehe Okoko, Department of Anatomy College of Medicine of the University of Lagos. This research was performed to characterize the antidiabetic and antioxidant effects of the ethanolic root bark extract of C. albidum on alloxanized diabetic rats. The animals were housed in well ventilated cages and kept under controlled environmental conditions of temperature (25 ± 5°C), relative humidity (50 ± 5°C) and 12 hour light / dark cycle They were fed ad libitum everyday with standard chow diet and were given free access to water
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