Abstract
To identify thermosensitive areas of brain, we exposed rats to warm or cool environments and used the expression of the protein Fos as a marker of neuronal activity. In hyperthermic, heat-exposed rats, the median preoptic nucleus, and the medial and lateral preoptic areas had significantly more Fos immunoreactive neurons than control or cold-exposed animals. These observations add to the physiologic evidence that neurons of the preoptic area participate in thermoregulation and provide a means to identify the neurotransmitter systems involved.
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