Abstract
Purpose: To determine knowledge regarding hypertension, adherence to medication and HealthRelated Quality of Life (HRQoL), and their associations in hypertensive patients in Pakistan.
 Methods: A cross-sectional study was conducted among 384 hypertensive patients attending a tertiary health care public sector hospital in Islamabad, Pakistan. Data were collected using knowledge questionnaire regarding hypertension, Morisky Medication Adherence Scale, and EuroQol (EQ-5D) scale.
 Results: The mean systolic and diastolic blood pressures of the 384 patients were 140.39 ± 15.485 and 88.74 ± 10.683 mmHg, respectively. The coefficient of correlation between knowledge regarding hypertension and adherence was 0.638 (p < 0.001), showing a positive association. The correlation coefficient between knowledge and HRQoL was 0.709 (p < 0.001), suggesting a good association. The correlation coefficient between adherence to medication and HRQoL was 0.545 (p < 0.001), which indicated a positive correlation.
 Conclusion: These results indicate that there are statistically significant associations between hypertension knowledge and HRQoL, hypertension knowledge and medication adherence, and between adherence and HRQoL in the hypertensive patients studied.
Highlights
Hypertension (HTN) is a chronic disease of worldwide concern
Three hundred and eighty-four (384) HTN patients were enrolled in this study
The results from the present study showed that among the HTN patients studied, knowledge regarding hypertension had good association with medication adherence
Summary
Hypertension (HTN) is a chronic disease of worldwide concern. It is an important and avoidable risk factor for cardiovascular diseases. Hypertension has substantial negative impacts on health, and results in needless morbidity and mortality. It is believed to be responsible for > 5.8 % of deaths worldwide, and loss of about 11.9 % of life expectancy. The success rate in control of hypertension is poor all over the world. Pakistan is faced with an epidemic of hypertension as well as cardiovascular (CV) diseases [1]. Life expectancy in Pakistan (62 years) is 17 – 20
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