Abstract
ABSTRACTRisperidone is one of the most commonly used antipsychotic agents in the treatment of psychosis in children and adults. However, it can lead to hyperprolactinaemia by blocking dopamine D2 receptors in the anterior pituitary. This can result in galactorrhea, menstrual irregularity, amenorrhoea and gynaecomastia and can impact adversely on medication compliance and quality of life. Very few data are available in the literature concerning the management of hyperprolactinaemia developing in association with antipsychotics in children and adolescents. This report describes improvement with the addition to treatment of low-dose aripiprazole in hyperprolactinaemia and menstrual irregularity emerging as side effects of risperidone therapy in an adolescent girl diagnosed with schizophrenia.
Highlights
Onset schizophrenia starts before the age of 18, is characterized by an adverse clinical course and poor psychosocial functioning, involves more negative symptoms than schizophrenia starting in adulthood, and causes problems in the social-cognitive sphere
We report a case of hyperprolactinaemia developing in an adolescent girl in association with risperidone use due to schizophrenia, with prolactin levels subsequently returning to normal following the addition to treatment of aripiprazole therapy
This report describes improvement with the addition to treatment of low-dose aripiprazole in hyperprolactinaemia and menstrual irregularity emerging as side effects following risperidone therapy in an adolescent patient diagnosed with schizophrenia
Summary
Onset schizophrenia starts before the age of 18, is characterized by an adverse clinical course and poor psychosocial functioning, involves more negative symptoms than schizophrenia starting in adulthood, and causes problems in the social-cognitive sphere. This report describes improvement with the addition to treatment of low-dose aripiprazole in hyperprolactinaemia and menstrual irregularity emerging as side effects of risperidone therapy in an adolescent girl diagnosed with schizophrenia. We report a case of hyperprolactinaemia developing in an adolescent girl in association with risperidone use due to schizophrenia, with prolactin levels subsequently returning to normal following the addition to treatment of aripiprazole therapy.
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