Abstract
Objective:The study was designed to determine the hyperlipidemia in breast cancer of patients at disease presentation, without any treatment and to correlate these variations with disease stage.Methods:This cross sectional study was conducted at Liaquat National teaching hospital in Karachi from 2006 to 2011, Age and family history of 208 breast cancer patients with infiltrating Ductal Carcinoma were compared with 176 matched control subjects. Married females were selected, with children and short breast feeding period. Cancer stage I-III was considered for the study and patients were grouped on the basis of Tumor grade, Tumor size, lymph node metastasis and disease free survival. Disease staging was based on tumor size and lymph node metastasis. Biochemical estimations included variations in random blood glucose level and lipid profile.Results:Lipid profile and random blood glucose level were found significantly high (p<0.05) compared to control subjects. Hyperlipidemia was significantly high in breast cancer patients with lymph node metastasis. On increase in tumor grade I to II, increase in total cholesterol (4%), LDL-cholesterol 23% and 11% increase in triglycerides was observed. On Tumor size increase from ≤2 to 2.5cm, increase observed in blood random glucose level was (4%), total cholesterol (1.7%) triglycerides (2%) and LDL (3%) whereas HDL was (2%) low. These variations remain insignificant on further increase in tumor size and grade.Conclusion:Study suggests that variation in lipid profile and blood random glucose level is associated with disease stage. No independent correlation of hyperlipidemia and hyperglycemia was developed with disease free survival.
Highlights
Lipids have always been held responsible for pathogenesis of cardiovascular diseases
Level of blood random glucose and lipid profile was significantly high in patients with lymph node metastasis as compared to that without lymph node metastasis ▲p
Patients were grouped on the basis of tumor histopathology including tumor grade, tumor size and axillary lymph node (ALN) metastasis status
Summary
Lipids have always been held responsible for pathogenesis of cardiovascular diseases. Correspondence: December 13, 2017 February 13, 2018 February 14, 2018 of circulating lipids with diseases including breast cancer.. In Pakistan incidence of occurrence is 2–5 times higher than other countries and one out of nine females suffer from this disease.. Breast cancer occurrence related hyperlipidemia was related with short breast feeding period, family breast cancer history due to mutation in BRCA1 and BRCA2.3 Obesity with high BMI was related with ER positive breast cancer irrespective of menopausal status.. Infiltrating ductal carcinoma is an invasive type of breast cancer arising from the duct and infiltrate into the surrounding tissues.. Cancer stages are I-III and IV, stages I-III define cancer spread with increase in tumor size and lymph Correspondence: December 13, 2017 February 13, 2018 February 14, 2018 of circulating lipids with diseases including breast cancer. In Pakistan incidence of occurrence is 2–5 times higher than other countries and one out of nine females suffer from this disease. Breast cancer occurrence related hyperlipidemia was related with short breast feeding period, family breast cancer history due to mutation in BRCA1 and BRCA2.3 Obesity with high BMI was related with ER positive breast cancer irrespective of menopausal status. Infiltrating ductal carcinoma is an invasive type of breast cancer arising from the duct and infiltrate into the surrounding tissues. Cancer stages are I-III and IV, stages I-III define cancer spread with increase in tumor size and lymph
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