Abstract
This report contains authors own data about hyperglycemia impact on main functional properties of endothelial cells, mesenchymal stem cells and circulating progenitor cells, which define their participation in angiogenesis. Obtained data shows that cultivation of endothelial cells in hyperglycemic conditions leads to decrease of their ability for targeted migration and vascular-like structures formation on matrigel, and to suppression of VEGF receptors expression in these cells. Mesenchymal stem cells cultivated in hyperglycemic conditions have altered expression profile, decreased ability to stimulate angiogenesis via paracrine activity. Hyperglycemia in CHD patients with concomitant diabetes mellitus type II most probably lead to circulating bone marrow progenitor cells mobilisation distortion in response to tissue ischemia and damage to the endothelium, that can infringe upon their participation in endothelium reparation and angio- and vasculogenesis in the ischemic conditions. Found distortions can be used as targets for the treatment aimed at cardiovascular complications prevention in diabetic patients.
Highlights
Хорошо известно, что сердечно-сосудистые осложнения — основная причина смерти больных сахарным диабетом
This report contains authors own data about hyperglycemia impact on main functional properties of endothelial cells, mesenchymal stem cells and circulating progenitor cells, which define their participation in angiogenesis
Obtained data shows that cultivation of endothelial cells in hyperglycemic conditions leads to decrease of their ability for targeted migration and vascular-like structures formation on matrigel, and to suppression of VEGF receptors expression in these cells
Summary
Влияние гипергликемии на ангиогенные свойства эндотелиальных и прогениторных клеток сосудов. У больных ишемической болезнью сердца, сочетающейся с сахарным диабетом 2 типа, гипергликемия, вероятно, приводит к нарушению мобилизации циркулирующих прогениторных клеток из костного мозга в ответ на ишемию тканей и повреждение эндотелия, что может нарушать их участие в репарации эндотелия и ангио- и васкулогенезе при ишемии. Процессы репарации сосуда и неоваскуляризации осуществляются при участии циркулирующих эндотелиальных предшественников, мобилизующихся из костного мозга в ответ на ишемию и повреждение сосудов. This report contains authors own data about hyperglycemia impact on main functional properties of endothelial cells, mesenchymal stem cells and circulating progenitor cells, which define their participation in angiogenesis. Hyperglycemia in CHD patients with concomitant diabetes mellitus type II most probably lead to circulating bone marrow progenitor cells mobilisation distortion in response to tissue ischemia and damage to the endothelium, that can infringe upon their participation in endothelium reparation and angio- and vasculogenesis in the ischemic conditions.
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