Abstract
Objective: To test the hypothesis that infection with Helicobacter pylori is associated with hyperemesis gravidarum.Methods: From January 1995 to November 1996 we enrolled 105 patients with hyperemesis gravidarum in a prospective study. The Helicobacter serum Immunoglobulin (Ig) G concentrations in these patients were compared with those in asymptomatic gravidas matched for week of gestation.Results: Positive serum IgG concentrations were found in 95 of the 105 hyperemesis patients (90.5%) compared with 60 of 129 controls (46.5%). A χ2 test showed statistical significance (P < .001). The mean (± standard deviation) index percentages of the IgG titers were 74.2 ± 23.6% in the hyperemesis group and 24.3 ± 4.4% in the control group (P < .01, Student t test).Conclusion: Infection with H pylori may cause hyperemesis gravidarum.
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