Abstract
Meeting Abstracts1 May 1972Hypercatabolism of Third Complement Component (C3) in Chronic Glomerulonephritis: Role of the Alternate Complement Pathway.L. G. Hunsicker, F.A.C.P., S. Ruddy, M.D., C. B. Carpenter, M.D., J. P. Merrill, F.A.C.P., H. J. Muller-Eberhard, M.D., K. F. Austen, F.A.C.P.L. G. Hunsicker, F.A.C.P.Search for more papers by this author, S. Ruddy, M.D.Search for more papers by this author, C. B. Carpenter, M.D.Search for more papers by this author, J. P. Merrill, F.A.C.P.Search for more papers by this author, H. J. Muller-Eberhard, M.D.Search for more papers by this author, K. F. Austen, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-874_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptObservations of circulating factors that destroy the third component of complement (C3) and of circulating split products of C3 suggest the depressions of serum C3 found in membranoproliferative glomerulonephritis are caused by activation with hypercatabolism. Complement (C3) can be activated either by the classical early complement components (Cl, C4, C2) or via the alternate complement pathway, utilizing the C3 proactivator (C3PA). Serum levels of C4 and C3PA have been measured by radial immunodiffusion in 18 patients with chronic hypocomplementemic (low C3) nephritis, to evaluate the participation of the classical and alternate pathways. Levels of C4 were uniformly normal. The C3PA... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass., and La Jolla, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 874-874KeywordsGlomerulonephritisNephritis Issue Published: 1 May 1972 PDF DownloadLoading ...
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