Abstract
A transplantable Ley dig cell tumor of the Fischer rat produces hypercalcemia and hypercalciuria. The behavior of this tumor has been studied in individual rats and groups of rats. Continued hypercalcemia leads to hypophosphatemia and azotemia and an eventual decrease in serum calcium and calcium excretion. A 23 factorial design elucidates the effects of tumor, castration, thyroparathyroidectomy and the interactions of these procedures on the level of serum calcium and excretion of calcium in the urine. The greatest changes in serum calcium and calcium excretion in the urine are seen in castrated and/or thyroparathyroidectomized groups of rats. These observations suggest a role for gonadotropins and thyrocalcitonin in the achievement of hypercalcemia. The effects of this tumor appear to make it an ideal model system for studying some forms of hypercalcemia associated with localized neoplasia. (Endocrinology 88: 1210, 1971)
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