Abstract
Author’s Reply Sir, In our study, there were not a significant number of patients withGilbert’s syndrome with pathological uroflow along with the pathological values of bilirubin, but we found interesting and valuable fact that they all had normal uroflow when the values of bilirubin in the serum were normalized. Each patient was a control of its own, postfasting uroflowmetry being experimental and post hypercaloric uroflowmetry, the control. As said, this was the first study working on this issue. A number of references were quoted where the authors have pointed out a possible relaxed effect of bilirubin on smooth muscles of gastric fundus and blood vessels (1, 2, 3, 4) and urinary tract muscles (5,6,7). It is proposed that bilirubin expressed the mentioned effect on smooth muscles by potentiating influence on NO relaxing effect. It is possible that other diseases except hyperbilirubinemia affect muscle relaxation of urinary tract (i.e. hyperglycemia), which is also mentioned in the article. Further examinations are required to confirm our conclusions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
