Abstract
A patient with persistently elevated levels of serum amylase activity is described. The amylase in the patient's serum was shown by gel filtration and ultracentrifugation to exist in macromolecular (7S) form. Attempts to coprecipitate the enzyme by treatment of the serum with polyvalent or specific antiserum were unsuccessful. However, the “macroamylase” reverted to amylase of normal size in acid conditions (pH 3.5). It had been shown previously that a feature of macroamylasemia is diminished renal clearance of amylase. Using this criterion it was demonstrated that none of the patient's four siblings had macroamylasemia; hence, it is unlikely to be an inherited condition.
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