Abstract
The rapid degradation rate of degradable magnesium alloys limits their application as orthopaedic implants. To improve the osteogenic activity and corrosion resistance of magnesium alloys, a hydroxyapatite/chitosan-metformin (HA/CS-MF) composite coating was prepared on AZ31 magnesium alloy by hydrothermal treatment. The structure and morphology of the composite coating were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), energy dispersive spectroscopy (EDS), and scanning electron microscopy (SEM). Electrochemical tests and hydrogen evolution experiments were carried out to evaluate the corrosion resistance of the HA/CS-MF composite coating. At the same time, the cytocompatibility, osseointegration ability and anti-inflammatory activity of the HA/CS-MF composite coating were studied. The findings revealed that the HA/CS-MF composite coating exhibits excellent corrosion resistance, biocompatibility and osteogenic activity; can upregulate the expression level of bone-related genes; and is conducive to the polarization of M2 macrophages.
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